PhysioLab

Click any problem to load it into the form. Covers pharmacokinetics, cardiovascular and respiratory physiology, biomechanics, medical statistics, and French examples.

• PharmacokineticsFirst-order eliminationA drug follows first-order elimination and has a half-life of 6 hours. What percentage of the initial dose remains after 18 hours?
• CardiovascularCardiac outputA patient has a heart rate of 75 beats per minute and a stroke volume of 70 mL. Calculate the cardiac output in litres per minute.
• CardiovascularPoiseuille resistanceBlood flows through a cylindrical vessel. According to Poiseuille's law, by what factor does resistance change if the vessel radius is reduced by half while all other variables remain constant?
• PharmacokineticsElimination curveA drug follows first-order elimination with a half-life of 6 hours. Plot the percentage of the initial dose remaining from 0 to 24 hours.
• CardiovascularMean arterial pressureA patient's blood pressure is 120/80 mmHg. Calculate the mean arterial pressure using MAP = (SBP + 2 × DBP) / 3.
• CardiovascularEjection fractionEnd-diastolic volume is 120 mL and end-systolic volume is 50 mL. Calculate the ejection fraction as a percentage.
• RespiratoryMinute ventilationTidal volume is 500 mL and respiratory rate is 12 breaths per minute. Calculate minute ventilation in litres per minute.
• RespiratoryAlveolar gas equationUsing the simplified alveolar gas equation PAO2 = 150 - PaCO2 / 0.8, calculate alveolar oxygen tension when PaCO2 is 40 mmHg.
• RespiratoryLung complianceLung volume increases by 0.5 L when transmural pressure increases by 5 cmH2O. Calculate compliance in L/cmH2O.
• PharmacokineticsLoading doseA drug has a volume of distribution of 40 L. What loading dose in mg is needed to achieve a target plasma concentration of 10 mg/L? Assume bioavailability is 100%.
• PharmacokineticsSteady-state infusionClearance of a drug is 5 L/h. What continuous infusion rate in mg/h maintains a steady-state concentration of 8 mg/L?
• General biomedicalBody mass indexA person weighs 70 kg and is 1.75 m tall. Calculate BMI in kg/m².
• General biomedicalAnion gapSerum Na+ is 140 mmol/L, Cl− is 104 mmol/L, and HCO3− is 24 mmol/L. Calculate the anion gap.
• General biomedicalHenderson–HasselbalchFor the bicarbonate buffer with pKa 6.1, calculate pH when [HCO3−] is 24 mmol/L and PaCO2 is 40 mmHg, using pH = 6.1 + log10(HCO3 / (0.03 × PaCO2)).
• BiomechanicsNernst potential (K+)At 37°C, the Nernst potential for potassium is EK = 61.5 × log10([K+]o / [K+]i). Calculate EK when extracellular K+ is 4 mmol/L and intracellular K+ is 140 mmol/L.
• BiomechanicsReynolds numberEstimate the Reynolds number for blood flow in a vessel of diameter 2 cm, mean velocity 40 cm/s, density 1.05 g/cm³, and viscosity 0.04 poise. Is flow more likely laminar or turbulent?
• Medical statisticsTest sensitivityA diagnostic test finds 80 true positives and 20 false negatives among people with disease. Calculate the sensitivity as a percentage.
• Medical statisticsPositive predictive valueA screening test yields 45 true positives and 15 false positives. Calculate the positive predictive value as a percentage.
• Medical statisticsOdds ratioIn a case-control study, exposed cases = 40, unexposed cases = 60, exposed controls = 20, unexposed controls = 80. Calculate the odds ratio.
• PharmacokineticsDemi-vie (FR)Un médicament suit une élimination d'ordre 1 avec une demi-vie de 6 heures. Quel pourcentage de la dose initiale reste après 18 heures ?
• CardiovascularDébit cardiaque (FR)Un patient a une fréquence cardiaque de 75 battements par minute et un volume d'éjection systolique de 70 mL. Calculez le débit cardiaque en litres par minute.
• RespiratoryVentilation minute (FR)Le volume courant est de 500 mL et la fréquence respiratoire de 12 cycles par minute. Calculez la ventilation minute en litres par minute.